Author
University of British ColumbiaORCID 0000-0002-1726-4198Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Corbin Glufka, Mahir Taher, Jerry Shijie Tong…·Kurt Z. Haas
SCADR assesses PTEN missense variants' effects on signaling pathways through single-cell phospho-antibody analysis, revealing variant-specific dysfunction profiles.
Fabian Meili, William Wei, Wun‐Chey Sin…·Kurt Z. Haas
The paper analyzes 58 SYNGAP1 variants using multiple assays to assess their impact on GTPase signaling, localization, and protein stability, revealing functional differences and pathogenicity classifications.
Barry P. Young, Kathryn L Post, Jesse T. Chao…·Christopher J. R. Loewen
The paper introduces a method to assess the functional impact of human disease gene variants using yeast-based assays.
Kathryn L. Post, Manuel Belmadani, Payel Ganguly…·Kurt Z. Haas
The paper evaluates 106 PTEN variants using 18 assays across 5 models to identify molecular mechanisms of dysfunction, finding that stability and domain-specific assays are critical for accurate impact assessment.
Troy A. McDiarmid, Manuel Belmadani, Joseph Liang…·Catharine H. Rankin
This study systematically analyzes ASD-associated genes in C. elegans, identifying phenotypic relationships and reversible impairments in habituation learning.