Manuel Belmadani

This study shows that loss of brain insulin production in female mice impairs learning and memory, while having no effect on males.

The paper uses long-read sequencing to catalog Cacna1e splice variants in rat thalamus and computationally identifies four functionally distinct isoforms.

The paper curates over 10,000 transcriptomic datasets to improve data reuse by standardizing metadata, processing, and annotations.

The paper evaluates 106 PTEN variants using 18 assays across 5 models to identify molecular mechanisms of dysfunction, finding that stability and domain-specific assays are critical for accurate impact assessment.

This study systematically analyzes ASD-associated genes in C. elegans, identifying phenotypic relationships and reversible impairments in habituation learning.

VariCarta aggregates and harmonizes genomic variants from ASD sequencing studies to prevent double-counting and improve association evidence.

This study assesses patch-seq, showing technical artifacts in single-cell transcriptomes and proposing a marker gene-based approach to improve gene expression-electrophysiological feature alignment.