GeneticsNature CommunicationsPeer-reviewed
Multi-model functionalization of disease-associated PTEN missense mutations identifies multiple molecular mechanisms underlying protein dysfunction
Kathryn L. Post, Manuel Belmadani, Payel Ganguly…·Kurt Z. Haas
The paper evaluates 106 PTEN variants using 18 assays across 5 models to identify molecular mechanisms of dysfunction, finding that stability and domain-specific assays are critical for accurate impact assessment.
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