Author

Daniel B. Callaghan

University of British Columbia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:differential expression· 1 Assay:protein structure· 1 Assay:proteomics· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Fabian MeiliiD· 2 shared Kurt Z. HaasiD· 2 shared Paul PavlidisiD· 2 shared Sanja RogićiD· 2 shared Warren M. MeyersiD· 2 shared Alessandro CauiD· 1 shared Ana P. Niciforovic· 1 shared Barry P. YoungiD· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenetics

Fabian MeiliORCID

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2 papers

Recent·Most cited

Multi-parametric analysis of 58 SYNGAP1 variants reveal impacts on GTPase signaling, localization and protein stability

Fabian Meili, William Wei, Wun‐Chey Sin, Warren M. Meyers, Iulia Dascalu, Daniel B. Callaghan, Sanja Rogić, Paul Pavlidis, Kurt Z. Haas

The paper analyzes 58 SYNGAP1 variants using multiple assays to assess their impact on GTPase signaling, localization, and protein stability, revealing functional differences and pathogenicity classifications.

The American Journal of Human Genetics · Dec 11, 2020Peer-reviewedGenetics

Multi-model functionalization of disease-associated PTEN missense mutations identifies multiple molecular mechanisms underlying protein dysfunction

Kathryn L. Post, Manuel Belmadani, Payel Ganguly, Fabian Meili, Riki Dingwall, Troy A. McDiarmid, Warren M. Meyers, Caitlin Herrington, Barry P. Young, Daniel B. Callaghan, Sanja Rogić, Matthew Edwards, Ana P. Niciforovic, Alessandro Cau, Catharine H. Rankin, , Kurt Z. Haas

The paper evaluates 106 PTEN variants using 18 assays across 5 models to identify molecular mechanisms of dysfunction, finding that stability and domain-specific assays are critical for accurate impact assessment.

Nature Communications · Apr 29, 2020Peer-reviewedGenetics