Obesity reprograms adipose extracellular vesicles to induce muscle atrophy via miR-150-5p-mediated transcriptional silencing
Joshua M. J. Price, Michael Macleod, Thomas A. Nicholson, Caitlin M Ditchfield, Bethy Airstone, Natalie Lachlan-Jiraskova, Edward T. Davis, Kostas Tsintzas, Simon Wyn Jones
This study shows that non-lean adipose extracellular vesicles induce muscle atrophy in older individuals via miR-150-5p-mediated transcriptional silencing.
bioRxiv · Dec 11, 2025 · PreprintCell Biology