Joshua M. J. Price

Infrapatellar Fat Pad Extracellular Vesicles Induce a Pro-Angiogenic VEGFAhigh/BMP4low Switch in Articular Chondrocytes: Implications for Chondrosarcoma

This study shows that infrapatellar fat pad extracellular vesicles increase VEGFA and decrease BMP4 in chondrocytes, promoting angiogenesis relevant to chondrosarcoma.

GLP-1 and GIP receptor agonism does not directly drive skeletal muscle atrophy or impair myogenesis in primary human myotubes

This study investigates whether GLP-1 and GIP receptor agonism directly causes skeletal muscle atrophy or impairs myogenesis in human myotubes, finding no significant effects.

Matrix viscoelasticity regulates dendritic cell migration and immune priming

This study shows that matrix viscoelasticity affects dendritic cell migration and immune responses by altering actomyosin dynamics and chromatin accessibility.

Feeder-free generation of functional dendritic cells from human pluripotent stem cells

This study develops a feeder-free method to generate functional human dendritic cells from pluripotent stem cells, outperforming monocyte-derived dendritic cells in antigen presentation and T cell activation.

Systemic drivers and molecular mechanisms of sarcopenia in aetiology-specific end-stage liver disease

This study identifies aetiology-specific molecular mechanisms of sarcopenia in end-stage liver disease by analyzing transcriptomic changes and cytokine profiles in muscle and plasma.

Human progenitor T-cell differentiation regulated by the mechanical resistance of thymus-mimetic extracellular matrices

This study shows that mechanical properties of thymus-mimetic matrices regulate human T-cell differentiation by modulating Notch1 and integrin signaling pathways.

Obesity reprograms adipose extracellular vesicles to induce muscle atrophy via miR-150-5p-mediated transcriptional silencing

This study shows that non-lean adipose extracellular vesicles induce muscle atrophy in older individuals via miR-150-5p-mediated transcriptional silencing.