Simon Wyn Jones

This study shows that infrapatellar fat pad extracellular vesicles increase VEGFA and decrease BMP4 in chondrocytes, promoting angiogenesis relevant to chondrosarcoma.

This study investigates whether GLP-1 and GIP receptor agonism directly causes skeletal muscle atrophy or impairs myogenesis in human myotubes, finding no significant effects.

This study identifies aetiology-specific molecular mechanisms of sarcopenia in end-stage liver disease by analyzing transcriptomic changes and cytokine profiles in muscle and plasma.

The paper develops a toolkit to measure multiple ageing hallmarks in human blood and tissue samples, identifying age-related changes in immune cells, senescence, and mitochondrial function.

This study shows that non-lean adipose extracellular vesicles induce muscle atrophy in older individuals via miR-150-5p-mediated transcriptional silencing.

This study finds increased intermuscular adipose tissue in chronic liver disease patients compared to controls, associated with altered muscle gene expression and reduced muscle function.

This study shows that activating GPR65 on fibroblast-like synoviocytes leads to inflammatory mediator release, contributing to joint pain in mice and humans.