Author

Michael Macleod

National Institute for Health and Care ResearchORCID 0009-0006-1977-2846Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:human· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Joshua M. J. PriceiD· 3 shared Simon Wyn JonesiD· 3 shared Caitlin DitchfieldiD· 2 shared Edward T. DavisiD· 2 shared Ahmed Mohamed ElsharkawyiD· 1 shared Amritpal DhaliwaliD· 1 shared Bethy Airstone· 1 shared Caitlin M Ditchfield· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersPhysiology

Joshua M. J. PriceORCID

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3 papers

Recent·Most cited

PhysiologybioRxivPreprintJul 23, 2026

GLP-1 and GIP receptor agonism does not directly drive skeletal muscle atrophy or impair myogenesis in primary human myotubes

Caitlin Ditchfield, Michael Macleod, Joshua M. J. Price…·Simon Wyn Jones

This study investigates whether GLP-1 and GIP receptor agonism directly causes skeletal muscle atrophy or impairs myogenesis in human myotubes, finding no significant effects.

DOI 10.64898/2026.07.20.739515

humanbulk RNA-seq

𝕏 PostBluesky

Molecular BiologyJournal of Cachexia Sarcopenia and MusclePeer-reviewedApr 26, 2026

Systemic drivers and molecular mechanisms of sarcopenia in aetiology-specific end-stage liver disease

Thomas Nicholson, S. Allen, Jonathan Iain Quinlan…·Simon Wyn Jones

This study identifies aetiology-specific molecular mechanisms of sarcopenia in end-stage liver disease by analyzing transcriptomic changes and cytokine profiles in muscle and plasma.

DOI 10.1002/jcsm.70294

humanbulk RNA-seq

𝕏 PostBluesky

Cell BiologybioRxivPreprintDec 11, 2025

Obesity reprograms adipose extracellular vesicles to induce muscle atrophy via miR-150-5p-mediated transcriptional silencing

Joshua M. J. Price, Michael Macleod, Thomas A. Nicholson…·Simon Wyn Jones

This study shows that non-lean adipose extracellular vesicles induce muscle atrophy in older individuals via miR-150-5p-mediated transcriptional silencing.

DOI 10.64898/2025.12.09.693129

humanbulk RNA-seq

𝕏 PostBluesky