Transcriptional Regulation of Protein Synthesis by Mediator Kinase in MYC-driven Medulloblastoma
Dong Wang, Caitlin Ritz, Angela Pierce, Breauna Brunt, Yuhuan Luo, Nathan Dahl, Sujatha Venkataraman, Etienne Danis, Kamil Kuś, Milena Mazan, Tomasz Rzymski, Bethany Veo, Rajeev Vibhakar
This study identifies CDK8 as a critical dependence in MYC-driven medulloblastoma, showing its role in regulating transcription and translation through mechanisms involving ribosome biogenesis and 4EBP1 phosphorylation.
bioRxiv · Mar 8, 2024 · PreprintCancer Biology