Accelerated loss of hypoxia response in zebrafish with familial Alzheimer's disease-like mutation of Presenilin 1.
Morgan Newman, Seyyed Hani Moussavi Nik, Greg Trevor Sutherland, Nhi Hin, Woojin Scott Kim, Glenda Margaret Halliday, Suman Jayadev, Carole Smith, Angela S. Laird, Caitlin W. Lucas, Thaksaon Kittipassorn, Dan Peet, Michael T. Lardelli
This study shows that zebrafish with PSEN1 mutations exhibit accelerated hypoxia response loss with age, suggesting a link between PSEN1 dysfunction and Alzheimer's disease pathogenesis.
Human Molecular Genetics · Jun 16, 2020Peer-reviewedGenomics