Nhi Hin

This study shows that zebrafish with PSEN1 mutations exhibit accelerated hypoxia response loss with age, suggesting a link between PSEN1 dysfunction and Alzheimer's disease pathogenesis.

The paper identifies IRE-containing genes and shows their expression changes are early markers of Alzheimer's disease in zebrafish, revealing species-specific differences in IRE transcript stability under iron dyshomeostasis.

This study uses a zebrafish model of familial Alzheimer’s disease to show accelerated brain aging and transcriptional inversion linked to glucocorticoid resistance and immune pathway changes before histopathology.

The paper analyzes transcriptomes of zebrafish with a familial Alzheimer's disease-like mutation in psen1, finding effects on mitochondrial ATP synthesis and ATP-dependent processes.