Author

Carole Smith

University of WashingtonORCID 0000-0003-2216-6004Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1 Organism:zebrafish· 1

Frequent Co-Authors

Suman JayadeviD· 2 shared Angela S. LairdiD· 1 shared Caitlin W. Lucas· 1 shared Dan Peet· 1 shared Glenda Margaret HallidayiD· 1 shared Greg Trevor SutherlandiD· 1 shared Kevin M. KnoxiD· 1 shared Megan Beckman· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersNeuroscience

Suman JayadevORCID

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2 papers

Recent·Most cited

NeuroscienceExperimental NeurologyPeer-reviewedJan 9, 2023

Chronic Seizures Induce Sex-Specific Cognitive Deficits with Loss of Presenilin 2 Function

Kevin M. Knox, Megan Beckman, Carole Smith…·Melissa L. Barker‐Haliski

This study shows chronic seizures worsen cognitive deficits in aged female PSEN2 KO mice but not males, with sex-specific changes in neuroinflammation and neuroplasticity.

13 citations

mouseexperimental assay

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GenomicsHuman Molecular GeneticsPeer-reviewedJun 16, 2020

Accelerated loss of hypoxia response in zebrafish with familial Alzheimer's disease-like mutation of Presenilin 1.

Morgan Newman, Seyyed Hani Moussavi Nik, Greg Trevor Sutherland…·Michael T. Lardelli

This study shows that zebrafish with PSEN1 mutations exhibit accelerated hypoxia response loss with age, suggesting a link between PSEN1 dysfunction and Alzheimer's disease pathogenesis.

15 citations

zebrafishhuman

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