Greg Trevor Sutherland

This paper presents an end-to-end framework for single-cell whole-transcriptome spatial profiling of post-mortem human brain tissue, improving library quality and enabling cross-sample harmonization.

This study creates a spatial ganglioside atlas for mouse and human brains using mass spectrometry imaging, revealing species-specific distributions and differences between species and brain regions.

This study measures trace metal levels in brain regions of individuals with and without alcohol use disorder, finding dysregulated iron and other metals, particularly in females.

The paper investigates cell-to-cell communication in Alzheimer's disease to characterize disease biology and suggest new avenues for therapeutic intervention.

This study identifies neuronal lysosomal acid lipase (LAL) loss as a driver of amyloid pathology in Alzheimer's disease by linking disrupted lipophagy to Aβ accumulation and cognitive deficits.

The paper identifies glial transcriptomic dysregulation and genetic risk in the cortex of individuals with Alcohol Use Disorder using single nuclei RNA-sequencing.

This study performs a cross-species meta-analysis of transcriptomic data from AUD patients and animal models to identify common differentially expressed genes and pathways involved in AUD.

The paper uses multiomic profiling of the caudate nucleus to identify gene expression and chromatin changes in AUD, linking them to risk genes through QTL analysis.

The paper identifies molecular and anatomical diversity in human cortical astrocytes and links adversity and glucocorticoid signalling to glutamate-related synaptic dysfunction in psychiatric disorders.

The paper introduces a statistical method to analyze highly multiplexed imaging data and identifies distinct tissue architectures across three high-parameter assays.

This study shows that zebrafish with PSEN1 mutations exhibit accelerated hypoxia response loss with age, suggesting a link between PSEN1 dysfunction and Alzheimer's disease pathogenesis.