Acquisition and extinction of drug-context memories are linked to distinct epigenetic and transcriptional mechanisms in the mouse dentate gyrus
Madelyn R. Baker, Rose K. Sciortino, Caitlin Zarley, Diego Scala-Chávez, Paul Bergin, Anjali M. Rajadhyaksha, Miklós Tóth
This study shows that drug-context memory acquisition and extinction in mice involve distinct epigenetic and transcriptional changes in the dentate gyrus, with non-overlapping genomic regions and gene functions.
bioRxiv · Mar 5, 2026 · PreprintAnimal Behavior & Cognition