Author

Madelyn R. Baker

Cornell UniversityORCID 0000-0002-4231-1857Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Animal Behavior & Cognition· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 3 Research Focus:gene regulatory network inference· 3 Organism:mouse· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2

Frequent Co-Authors

Miklós TóthiD· 3 shared Anjali M. RajadhyakshaiD· 2 shared Elizabeth BrindleyiD· 2 shared Rose K. SciortinoiD· 2 shared Caitlin Zarley· 1 shared Diego Scala-CháveziD· 1 shared Faten TakiiD· 1 shared Judit Gal TothiD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersNeuroscience

Miklós TóthORCID

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3 papers

Recent·Most cited

Large-scale reorganization of DNA methylation and upregulation of extracellular matrix genes in the dorsal dentate gyrus following cocaine taking

Madelyn R. Baker, Elizabeth Brindley, Kyle A. Windisch, Rose K. Sciortino, Anjali M. Rajadhyaksha, Miklós Tóth

This study shows cocaine self-administration causes large-scale DNA methylation changes and upregulation of extracellular matrix genes in the dorsal dentate gyrus of mice.

Translational Psychiatry · Sep 15, 2026Peer-reviewedNeuroscience

Acquisition and extinction of drug-context memories are linked to distinct epigenetic and transcriptional mechanisms in the mouse dentate gyrus

Madelyn R. Baker, Rose K. Sciortino, Caitlin Zarley, Diego Scala-Chávez, Paul Bergin, Anjali M. Rajadhyaksha, Miklós Tóth

This study shows that drug-context memory acquisition and extinction in mice involve distinct epigenetic and transcriptional changes in the dentate gyrus, with non-overlapping genomic regions and gene functions.

bioRxiv · Mar 5, 2026 · PreprintAnimal Behavior & Cognition

Regions with intermediate DNA methylation are epigenomic hotspots governing behavioral adaptation to changing environments

Elizabeth Brindley, Faten Taki, Shannon C. Odell, Madelyn R. Baker, Judit Gal Toth, Miklós Tóth

The paper identifies epigenetically bistable DNA methylation regions in hippocampal granule cells that are linked to behavioral adaptation to environmental changes.

bioRxiv · Dec 11, 2022 · PreprintNeuroscience