Anjali M. Rajadhyaksha

Large-scale reorganization of DNA methylation and upregulation of extracellular matrix genes in the dorsal dentate gyrus following cocaine taking

This study shows cocaine self-administration causes large-scale DNA methylation changes and upregulation of extracellular matrix genes in the dorsal dentate gyrus of mice.

Reversible m6Am methylation of snRNA by FTO controls morphine reward and tolerance without altering analgesia

This study shows that FTO regulates morphine reward and tolerance through m6Am methylation of snRNA, without affecting analgesia.

Pharmacological Stratification of Public Bioactivity Databases: A Reusable, OECD-Anchored Curation and Benchmarking Framework Demonstrated for Opioid Receptors

This paper introduces a framework to stratify pharmacological data by action type and assay readout, improving QSAR model validity for opioid receptors.

Deletion of Cacna1c (CaV1.2) in D1-expressing cells elicits divergent sex-specific effects on aversive and spatial memories

This study investigates sex-specific effects of Cacna1c deletion in D1-expressing cells on fear and spatial memory in mice, revealing differential impacts on male and female behavior.

Acquisition and extinction of drug-context memories are linked to distinct epigenetic and transcriptional mechanisms in the mouse dentate gyrus

This study shows that drug-context memory acquisition and extinction in mice involve distinct epigenetic and transcriptional changes in the dentate gyrus, with non-overlapping genomic regions and gene functions.

Interneuron FGF13 regulates seizure susceptibility via a sodium channel-independent mechanism

This study identifies FGF13's role in seizure susceptibility through interneuron-specific knockout mice, revealing a sodium channel-independent mechanism involving K+ channel regulation.

Elevating levels of the endocannabinoid 2-arachidonoylglycerol blunts opioid reward but not analgesia

This study shows that increasing 2-AG levels reduces opioid reward but not analgesia in mice, suggesting a potential therapeutic strategy for pain treatment.

Cerebellar output neurons impair non-motor behaviors by altering development of extracerebellar connectivity

This study shows that ablating cerebellar output neurons has less impact on behavior than genetic mutations in these neurons, which cause additional deficits in learning and memory.

Repeat investigation during social preference behavior is suppressed in male mice with prefrontal cortex cacna1c (Cav1.2)-deficiency through the dysregulation of neural dynamics

This study shows that reduced Cav1.2 channels in the prefrontal cortex of male mice impair sustained social preference during repeat investigations, linked to altered neural activity.

A machine learning approach to predicting autism risk genes: Validation of known genes and discovery of new candidates

This study uses machine learning to predict autism risk genes by integrating gene expression, constraint metrics, and variation features, identifying known and novel candidates.