Rose K. Sciortino

This study shows that reducing LINE-1 RNA in hippocampal neurons increases their firing capacity and expands neuronal ensembles, improving spatial memory but reducing pattern separation.

This study shows cocaine self-administration causes large-scale DNA methylation changes and upregulation of extracellular matrix genes in the dorsal dentate gyrus of mice.

This study shows that drug-context memory acquisition and extinction in mice involve distinct epigenetic and transcriptional changes in the dentate gyrus, with non-overlapping genomic regions and gene functions.

This study shows that capillary neutrophil stalling contributes to reduced cerebral blood flow in high salt diet but not to tau phosphorylation or cognitive impairment.

The paper identifies epigenomic and transcriptomic changes in the ventral dentate gyrus of mice exposed to prenatal adversity, linking these changes to anxiety-like behavior.

This study identifies meningeal IL-17-producing T cells as a key driver of cognitive impairment in hypertension, showing their role in activating brain macrophages and suggesting therapeutic targets.