Dorsal root ganglia control nociceptive input to the central nervous system
Han Hao, Rosmaliza Binti Ramli, Caixue Wang, Chao Liu, Shihab S. Shah, Pierce N. Mullen, Varinder K. Lall, Frederick Jones, Jicheng Shao, Hailin Zhang, David B. Jaffe, Nikita L. Gamper, Xiaona Du
The paper demonstrates that dorsal root ganglia (DRG) filter nociceptive signals through axonal t-junctions, with GABAergic cells enhancing this filtering and reducing pain hypersensitivity in models of inflammation and neuropathy.
PLoS Biology · Jan 5, 2023Peer-reviewedNeuroscience