Shihab S. Shah

The paper identifies peptides based on the autoinhibitory XY linker of PLCβ isoforms that inhibit PLCβ activity and reduce inflammation and pain in a mouse model.

This study identifies DBI as a glial messenger that modulates mechanosensation through GABAA receptor interaction in DRG, offering a new therapeutic target for pain management.

The paper demonstrates that dorsal root ganglia (DRG) filter nociceptive signals through axonal t-junctions, with GABAergic cells enhancing this filtering and reducing pain hypersensitivity in models of inflammation and neuropathy.

This study identifies JPH4 as essential for ER-PM junction formation and inflammatory pain through SOCE and Ca2+ signaling in rat DRG neurons.