The Rtf1/Prf1-dependent histone modification axis and Rpb1 C-terminal domain phosphorylation counteract multi-drug resistance in fission yeast
Jennifer J. Chen, Calvin Moy, Viviane Pagé, Cian Monnin, Ziad W. El‐Hajj, Daina Zofija Avizonis, Rodrigo Reyes‐Lamothe, Jason C. Tanny
The paper identifies a gene regulatory function of the Rtf1-H2Bub1-H3K4me axis and Rpb1 CTD in controlling fungal drug tolerance by linking them to resistance against hydroxyurea and azole antifungals.
bioRxiv · Nov 24, 2023 · PreprintMolecular Biology