Daina Zofija Avizonis

This paper shows that viral inhibition of the APC/C enhances replication by increasing nucleotide pools through stabilization of biosynthesis enzymes.

This study identifies a lactate-fueled metabolon involving LDHB and HTC that promotes breast cancer metastasis by reprogramming NAD metabolism.

This study shows that mitochondrial ETF insufficiency promotes cancer growth by reprogramming bioenergetics and signaling pathways in neoplastic cells.

This study shows that EZH2 inhibition in TNBC causes metabolic stress, making cells more sensitive to glutaminase inhibitors.

This study shows that both mTOR activation and inhibition increase H3K27me3 through distinct mechanisms, and this epigenetic change correlates with the anti-proliferative effects of mTOR inhibitors.

The paper identifies a gene regulatory function of the Rtf1-H2Bub1-H3K4me axis and Rpb1 CTD in controlling fungal drug tolerance by linking them to resistance against hydroxyurea and azole antifungals.

This study shows that paclitaxel induces cADPR production via Sarm1, increasing intra-axonal calcium and causing axon degeneration, with cADPR antagonists preventing neuropathy without affecting chemotherapy efficacy.