Development of NanoBRET cellular target engagement assays in primary neurons for activating mutants of p21-activated kinase 1
Jacob L. Capener, Abdiel Badillo-Martinez, Bassel Awada, Zachary W. Davis‐Gilbert, Thomas Krämer, Cameron S. Blair, Frances M. Bashore, Hassan Al‐Ali, Alison Donnelly Axtman
This paper develops NanoBRET assays for PAK1 and its mutant in primary neurons to evaluate inhibitor target engagement.
ACS Chemical Neuroscience · Oct 6, 2026Peer-reviewedPharmacology & Toxicology