Bassel Awada

This paper identifies GAK as a novel mitotic kinase and therapeutic target in DLBCL, showing that GAK inhibition causes mitotic defects and that existing drugs can be repurposed for its targeting.

This paper develops NanoBRET assays for PAK1 and its mutant in primary neurons to evaluate inhibitor target engagement.

The paper shows co-inhibition of AGC kinases enhances CNS neuron regeneration and identifies TMP-316 as a drug candidate achieving this in a rat model.

This paper develops and validates a lumbar intrathecal catheterization method in rats for reliable drug delivery to the brain and confirms supraspinal pharmacodynamic target engagement.

The paper identifies novel compounds that reduce lipid droplet accumulation in podocytes by inducing lipophagy, offering potential therapeutic benefits for lipid metabolism disorders.