Author

Jacob L. Capener

University of North Carolina at Chapel HillORCID 0000-0001-5051-2010Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Assay:proteomics· 2 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Alison Donnelly AxtmaniD· 3 shared Frances M. BashoreiD· 3 shared Thomas KrämeriD· 2 shared Abdiel Badillo-MartineziD· 1 shared Ani MichaudiD· 1 shared Bassel AwadaiD· 1 shared Blair L. StrangiD· 1 shared Cameron S. Blair· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersPharmacology & Toxicology

Alison Donnelly AxtmanORCID

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3 papers

Recent·Most cited

Pharmacology & ToxicologyACS Chemical NeurosciencePeer-reviewedOct 6, 2026

Development of NanoBRET cellular target engagement assays in primary neurons for activating mutants of p21-activated kinase 1

Jacob L. Capener, Abdiel Badillo-Martinez, Bassel Awada…·Alison Donnelly Axtman

This paper develops NanoBRET assays for PAK1 and its mutant in primary neurons to evaluate inhibitor target engagement.

1 citation

mouseproteomics

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Pharmacology & ToxicologyJournal of Medicinal ChemistryPeer-reviewedJan 26, 2026

Development of a chemical probe to enable characterization of the casein kinase 1γ subfamily

Jacob L. Capener, Thomas Krämer, Frances M. Bashore…·Alison Donnelly Axtman

The paper develops a chemical probe, SGC-CK1γ-1, for the CK1γ subfamily, showing potent and selective inhibition of CK1γ kinases, WNT signaling, and HCMV replication.

4 citationstop 3%

experimental assaydrug response / drug discovery

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Cell BiologyFrontiers in Chemical BiologyPeer-reviewedJul 29, 2024

Development of SYK NanoBRET Cellular Target Engagement Assays for Gain-of-Function Variants

Jacob L. Capener, James D. Vasta, Vittorio L. Katis…·Frances M. Bashore

The paper develops a NanoBRET assay to study SYK gain-of-function variants in live cells and demonstrates inhibitor efficacy against these variants.

6 citations

humanproteomics

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