Hassan Al‐Ali

The cyclin-G associated kinase (GAK) is a novel mitotic kinase and therapeutic target in diffuse large B-cell lymphoma

This paper identifies GAK as a novel mitotic kinase and therapeutic target in DLBCL, showing that GAK inhibition causes mitotic defects and that existing drugs can be repurposed for its targeting.

Development of NanoBRET cellular target engagement assays in primary neurons for activating mutants of p21-activated kinase 1

This paper develops NanoBRET assays for PAK1 and its mutant in primary neurons to evaluate inhibitor target engagement.

AGC kinase homology requires and enables co-targeting for CNS regeneration

The paper shows co-inhibition of AGC kinases enhances CNS neuron regeneration and identifies TMP-316 as a drug candidate achieving this in a rat model.

Lumbar intrathecal catheterization in rats targeting the cerebral cortex: a drug delivery method and validation

This paper develops and validates a lumbar intrathecal catheterization method in rats for reliable drug delivery to the brain and confirms supraspinal pharmacodynamic target engagement.

Novel Lipophagy Inducers as Potential Therapeutics for Lipid Metabolism Disorders

The paper identifies novel compounds that reduce lipid droplet accumulation in podocytes by inducing lipophagy, offering potential therapeutic benefits for lipid metabolism disorders.