Distinct regulation of collagen biosynthesis by hypoxia and vitamin C uncovers an essential role for CXCL12-CXCR4 signaling
Méline Ricol, Cindy Dieryckx, Camille Callies, Sandrine Vadon‐Le Goff, Jean‐Baptiste Vincourt, Catherine Moali, Violaine Sée
This study shows that ascorbic acid and hypoxia regulate collagen biosynthesis through distinct mechanisms, with AA enhancing secretion via CXCL12-CXCR4 signaling and hypoxia increasing hydroxylation.
bioRxiv · Sep 17, 2026 · PreprintCell Biology