Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors
He Qian, Qingning Yuan, Hong Shan, Canrong Wu, Yimin Gu, Kaichun Wu, Wen Hu, Yumu Zhang, Xinheng He, H. Eric Xu, Lihua Zhao
This study presents cryo-EM structures of MCH-activated MCHR1 and MCHR2 with G-proteins, revealing ligand recognition mechanisms and activation pathways.
Cell Discovery · May 6, 2024Peer-reviewedMolecular Biology