Author

Yumu Zhang

Chinese Academy of SciencesORCID 0009-0003-8564-8964Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

H. Eric XuiD· 2 shared Xinheng HeiD· 2 shared Canrong Wu· 1 shared Chongzhao YouiD· 1 shared He Qian· 1 shared Hong ShaniD· 1 shared Kaichun WuiD· 1 shared Lihua ZhaoiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMolecular Biology

H. Eric XuORCID

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2 papers

Recent·Most cited

Molecular Mechanism of pH Sensing and Activation in GPR4 Reveals Proton-Mediated GPCR Signaling

Chongzhao You, Shimeng Guo, Tianwei Zhang, Xinheng He, Tianyu Gao, Wenwen Xin, Zining Zhu, Yujie Lu, Youwei Xu, Zhen Li, Yumu Zhang, Xi Cheng, Yi Jiang, Xin Xie, H. Eric Xu

This study reveals the molecular mechanism of pH sensing and activation in GPR4 through cryo-EM structures, showing proton-driven conformational changes and lipid modulation.

Cell Discovery · Jun 24, 2025Peer-reviewedMolecular Biology

Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors

He Qian, Qingning Yuan, Hong Shan, Canrong Wu, Yimin Gu, Kaichun Wu, Wen Hu, Yumu Zhang, Xinheng He, H. Eric Xu, Lihua Zhao

This study presents cryo-EM structures of MCH-activated MCHR1 and MCHR2 with G-proteins, revealing ligand recognition mechanisms and activation pathways.

Cell Discovery · May 6, 2024Peer-reviewedMolecular Biology