Author

Kaichun Wu

Chinese Academy of SciencesORCID 0000-0002-0699-9666Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:protein structure· 2 Research Focus:protein structure prediction· 2 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

H. Eric XuiD· 2 shared Qingning YuaniD· 2 shared Wen HuiD· 2 shared Xinheng HeiD· 2 shared Adrian R. LaciakiD· 1 shared Alec W. FreyniD· 1 shared Amy Gorrie· 1 shared Andrea Carfı́iD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMolecular Biology

H. Eric XuORCID

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3 papers

Recent·Most cited

mRNA-1273.251 and mRNA-1283.251 vaccines expressing SARS-CoV-2 variant LP.8.1 antigens broadly neutralize contemporary JN.1-lineage viruses

Arshan Nasir, Diana Wing Lee, Ziqiu Wang, Clinton O. Ogega, Nathen E. Bopp, Phylicia Wisti, Daniel L. Makrinos, Hardik Jani, Amy Gorrie, Michael F. Bender, Adrian R. Laciak, Arvind Sharma, Xiaozhen Hu, Tessa Speidel, Fadi Ghantous, , Alec W. Freyn

This study develops and evaluates two mRNA vaccines targeting the LP.8.1 variant of SARS-CoV-2, showing broad neutralization against JN.1-lineage subvariants.

bioRxiv · Sep 16, 2025 · PreprintImmunology

Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors

He Qian, Qingning Yuan, Hong Shan, Canrong Wu, Yimin Gu, Kaichun Wu, Wen Hu, Yumu Zhang, Xinheng He, H. Eric Xu, Lihua Zhao

This study presents cryo-EM structures of MCH-activated MCHR1 and MCHR2 with G-proteins, revealing ligand recognition mechanisms and activation pathways.

Cell Discovery · May 6, 2024Peer-reviewedMolecular Biology

Structural basis of peptide recognition and activation of endothelin receptors

Yujie Ji, Jia Duan, Qingning Yuan, Xinheng He, Gong Yang, Shengnan Zhu, Kaichun Wu, Wen Hu, Tianyu Gao, Xi Cheng, Hualiang Jiang, H. Eric Xu, Yi Jiang

The paper presents cryo-EM structures of endothelin receptors bound to ligands, revealing their recognition mode and activation mechanism.

Nature Communications · Mar 7, 2023Peer-reviewedMolecular Biology