Structural Insights into Selective and Dual Antagonism of EP2 and EP4 Prostaglandin Receptors
Yanli Wu, Heng Zhang, Jiuyin Xu, Kai Wu, Wen Hu, Xinheng He, Gaoming Wang, Canrong Wu, H. Eric Xu
The paper presents cryo-EM structures of EP2 and EP4 receptors with antagonists, revealing structural differences that explain selectivity and binding modes.
The EMBO Journal · Oct 29, 2025Peer-reviewedBiochemistry