Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology
Anna M. Castano, Margaux Silvestre, Carrow I. Wells, Jennifer L. Sanderson, Carla A. Ferrer, Han Wee Ong, Yi Liang, William A. Richardson, Josie A. Silvaroli, Frances M. Bashore, Jeffery L. Smith, Isabelle M Genereux, Kelvin Dempster, David Harold Drewry, Navlot S Pabla, , Alison Donnelly Axtman
The paper develops specific CDKL5 inhibitors that do not affect GSK3β activity and shows their effects on synaptic function and LTP in rat hippocampal slices.
eLife · Jul 25, 2023Peer-reviewedNeuroscience