Alex N. Bullock

The paper identifies how neomorphic KBTBD4 mutations and the drug UM171 recruit HDAC1/2 complexes through structural mimicry, revealing a common mechanism for their degradation.

This study shows that loss of IVNS1ABP causes a progeroid neuropathy by impairing proteostasis, leading to protein aggregation and lysosomal dysfunction in neuronal cells.

This paper reveals the structural basis of KCTD1's pentameric assembly and TFAP2A binding, identifying a novel ion-binding channel involved in its function.

The paper identifies and characterizes a chemical probe for CDKL2, demonstrating its selectivity and biological impact in neurons and cancer cells.

The paper develops specific CDKL5 inhibitors that do not affect GSK3β activity and shows their effects on synaptic function and LTP in rat hippocampal slices.

The paper determines the crystal structure of the KEAP1-CUL3 complex and develops a TR-FRET assay to study its binding, showing CDDO reduces affinity without disrupting the interaction.

This paper determines the crystal structure of KLHL3 in complex with a WNK3 peptide, revealing structural features and phosphorylation-dependent regulation of WNK3 binding.

The paper identifies and characterizes anti-TREM2 scFv antibodies that inhibit soluble TREM2 production.

The paper identifies saracatinib as a potent ALK2 inhibitor effective in preventing heterotopic ossification in FOP models.

The paper determines the crystal structure of the BMPR2 kinase domain and analyzes how disease-associated mutations affect its stability and potential for therapeutic intervention.

The paper determines the crystal structure of the KLHL20-DAPK1 complex, revealing the molecular basis of DAPK1 recruitment to the KLHL20 E3 ligase and suggesting a novel target for PROTAC-based drug design.