Treatment-Resilient Lipid Remodeling Defines Temozolomide Resistance and Failure of Simvastatin Sensitization in Glioblastoma
Kianoosh Naghibzadeh, Hyunjin Cho, Amir Barzegar Behrooz, Mahboubeh Kavoosi, Marco Cordani, Marek Łoś, Stevan Pecic, Carla Vitorino, Carla Vitorino, Amir Ravandi, Shahla Shojaei, Saeid Ghavami
This paper identifies treatment-resilient lipid remodeling in TMZ-resistant glioblastoma cells, showing that resistance is linked to coordinated changes in multiple lipid families rather than single species.
bioRxiv · Sep 26, 2026 · PreprintCancer Biology