Author

Kianoosh Naghibzadeh

University of ManitobaORCID 0000-0002-7423-7348Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 3 Assay:metabolomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Amir Barzegar BehrooziD· 3 shared Amir RavandiiD· 3 shared Saeid GhavamiiD· 3 shared Shahla ShojaeiiD· 3 shared Stevan PeciciD· 3 shared Abhay SrivastavaiD· 2 shared Courtney Jessica Clark· 2 shared Mehdi EshraghiiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

Amir Barzegar BehroozORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Treatment-Resilient Lipid Remodeling Defines Temozolomide Resistance and Failure of Simvastatin Sensitization in Glioblastoma

Kianoosh Naghibzadeh, Hyunjin Cho, Amir Barzegar Behrooz, Mahboubeh Kavoosi, Marco Cordani, Marek Łoś, Stevan Pecic, Carla Vitorino, Carla Vitorino, Amir Ravandi, Shahla Shojaei, Saeid Ghavami

This paper identifies treatment-resilient lipid remodeling in TMZ-resistant glioblastoma cells, showing that resistance is linked to coordinated changes in multiple lipid families rather than single species.

bioRxiv · Sep 26, 2026 · PreprintCancer Biology

Autophagy Cholesterol Axis Remodeling Supports Malignant Progression and Chemoresistance in Glioma

Shahla Shojaei, Amir Barzegar Behrooz, Kianoosh Naghibzadeh, João Luiz Martins Basso, Javad Alizadeh, Tania Dehesh, Roham Saberi, Bhavya Bhushan, Mehdi Eshraghi, Simone CDS Rosa, Courtney Jessica Clark, Mateusz M. Tomczyk, Laura Cole, Grant Michael Hatch, Vernon Wayne Dolinsky, , Saeid Ghavami

This study shows that autophagy and cholesterol metabolism are remodeled in glioma progression and TMZ resistance, with impaired autophagy linked to reduced cholesterol synthesis and altered lipid profiles.

bioRxiv · Jan 20, 2026 · PreprintCancer Biology

BCL2L13 Influences Autophagy and Ceramide Metabolism without Affecting Temozolomide Resistance in Glioblastoma

Courtney Jessica Clark, Amir Barzegar Behrooz, Simone C. da Silva Rosa, Kianoosh Naghibzadeh, Mehdi Eshraghi, Joadi Jacobs, Xiaohui Weng, Abhay Srivastava, Rui Miguel Pinheiro Vitorino, Sudharsana Rao Ande, Amir Ravandi, Sanjiv Dhingra, Stevan Pecic, Donald Miller, Shahla Shojaei, Saeid Ghavami

This study identifies BCL2L13 as a regulator of autophagy and ceramide metabolism in glioblastoma, showing distinct effects on metabolic pathways in TMZ-resistant and sensitive cells.

bioRxiv · Aug 23, 2024 · PreprintCancer Biology