Stevan Pecic

Treatment-Resilient Lipid Remodeling Defines Temozolomide Resistance and Failure of Simvastatin Sensitization in Glioblastoma

This paper identifies treatment-resilient lipid remodeling in TMZ-resistant glioblastoma cells, showing that resistance is linked to coordinated changes in multiple lipid families rather than single species.

Exploratory Network Analysis of Oral Bacteria Taste Signaling Autophagy Crosstalk in Oral Squamous Cell Carcinoma and Multi-Target Ligand Design for the MAPK1 STAT3 mTOR Axis

The paper integrates systems biology and machine learning to analyze bacterial signaling networks in OSCC, identifies key nodes, and designs multi-target ligands for the MAPK1-STAT3-mTOR axis.

Autophagy Cholesterol Axis Remodeling Supports Malignant Progression and Chemoresistance in Glioma

This study shows that autophagy and cholesterol metabolism are remodeled in glioma progression and TMZ resistance, with impaired autophagy linked to reduced cholesterol synthesis and altered lipid profiles.

Small Molecule Disruption of a Protein Disulfide Isomerase-Containing Multi-Protein Complex Causes Broad Cancer Selective Metabolic Collapse and Tumor Inhibition in vivo

PAV-620 and PAV-805 disrupt PDI-containing complexes, causing metabolic collapse and tumor inhibition in cancer models without toxicity to healthy cells.

BCL2L13 Influences Autophagy and Ceramide Metabolism without Affecting Temozolomide Resistance in Glioblastoma

This study identifies BCL2L13 as a regulator of autophagy and ceramide metabolism in glioblastoma, showing distinct effects on metabolic pathways in TMZ-resistant and sensitive cells.