Story about honest mistakes: The cyanobacterium Synechocystis has a promiscuous Entner-Doudoroff (ED) aldolase but no functional ED pathway.
Ravi Shankar Ojha, Marius L. Theune, Ruben Fritsche, Alexander Makowka, Marko Boehm, Carmen Peraglie, Christopher Bräsen, Jacky L. Snoep, Martin Hagemann, Bettina Siebers, Kirstin Gutekunst
This study revisits the claim of the Entner-Doudoroff pathway in Synechocystis, showing that while the aldolase is present, the full pathway is absent due to missing enzymes and experimental errors.
bioRxiv · Jul 23, 2026 · PreprintMicrobiology