Author

Marius L. Theune

University of KasselORCID 0000-0002-9130-7360Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:C. elegans· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Assay:proteomics· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Kirstin GutekunstiD· 3 shared Marko BoehmiD· 3 shared Ruben Fritsche· 2 shared A.E. Klon· 1 shared Alexander MakowkaiD· 1 shared Anika WiegardiD· 1 shared Bettina SiebersiD· 1 shared Carmen Peraglie· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersMicrobiology

Kirstin GutekunstORCID

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3 papers

Recent·Most cited

Story about honest mistakes: The cyanobacterium Synechocystis has a promiscuous Entner-Doudoroff (ED) aldolase but no functional ED pathway.

Ravi Shankar Ojha, Marius L. Theune, Ruben Fritsche, Alexander Makowka, Marko Boehm, Carmen Peraglie, Christopher Bräsen, Jacky L. Snoep, Martin Hagemann, Bettina Siebers, Kirstin Gutekunst

This study revisits the claim of the Entner-Doudoroff pathway in Synechocystis, showing that while the aldolase is present, the full pathway is absent due to missing enzymes and experimental errors.

bioRxiv · Jul 23, 2026 · PreprintMicrobiology

Easy-to-use whole-genome sequencing workflows and standardized practices to uncover hidden genetic variation in Synechocystis PCC 6803 wild-type and knock-out strains

Marius L. Theune, Ruben Fritsche, Niklas Kueppers, Marko Boehm, Petra Kolkhof, Florian Paul, Ovidiu Popa, Ellen Oldenburg, Anika Wiegard, Ilka Maria IM Axmann, Kirstin Gutekunst

This paper develops workflows for whole-genome sequencing to identify genetic variation in Synechocystis strains and highlights the importance of strain validation in knock-out studies.

bioRxiv · Apr 15, 2026 · PreprintMicrobiology

Structural basis of the allosteric regulation of cyanobacterial glucose-6-phosphate dehydrogenase by the redox sensor OpcA

Sofía Doello, Dmitry Shvarev, Marius L. Theune, Jakob Sauerwein, A.E. Klon, Erva Keskin, Marko Boehm, Kirstin Gutekunst, Karl Forchhammer

The paper investigates how OpcA regulates G6PDH in cyanobacteria through redox-dependent conformational changes, revealing a novel allosteric mechanism.

Proceedings of the National Academy of Sciences · Dec 6, 2024Peer-reviewedMolecular Biology