Molecular basis of Cyclin B1-CDK1 recruitment by MAD1
Mihkel Ord, Natalia de Martin Garrido, Matthew J. Winters, Mythili S. Subbanna, Johanna Kliche, Caroline Benz, Sophie L. Williams, Ylva Ivarsson, Basil J. Greber, Peter M. Pryciak, Norman E. Davey
The paper identifies a non-canonical helical binding motif in MAD1 that specifically interacts with Cyclin B1 to recruit CDK1 to the SAC, revealing a mechanism for B-type cyclin recognition.
bioRxiv · Nov 3, 2026 · PreprintMolecular Biology