Deletion of the polarity protein Llgl1 impairs cardiomyocyte intercalated disc integrity and permits cell cycle activity into adulthood
Jerrell J. Lovett, Michael A. Flinn, Amirala Bakhshian Nik, Anooj Arkatkar, Caelan W. Moreno, Caroline Greenheck, Sydney L. Buday, Kaelin A. Akins, Brianna R Waack, J. Pindaro, Alexandra L. Purdy, S. -J. Li, Bradley Miller, Lu Han, Chun Liu, , Caitlin Claire O'Meara
This study shows that deleting Llgl1 in cardiomyocytes disrupts intercalated disc integrity, causes electrical conduction defects, and allows cell cycle activity into adulthood, while improving cardiac function after injury.
bioRxiv · Dec 23, 2025 · PreprintCell Biology