Chun Liu

This study uses Perturb-seq with CRISPRi to analyze how cardiac and vascular transcription factors coordinate lineage commitment and cross-lineage signaling in human cardiac organoids.

This study shows that deleting Llgl1 in cardiomyocytes disrupts intercalated disc integrity, causes electrical conduction defects, and allows cell cycle activity into adulthood, while improving cardiac function after injury.

This study shows PM curvature promotes ER-PM contact formation in cardiomyocytes via junctophilin-EHD interactions.

This study demonstrates an efficient chemical method to generate iPSCs from frozen umbilical cord tissue, highlighting its safety and potential for regenerative medicine.

The paper uses transcriptomic data to identify potential drug therapies for a monogenic disease by finding FDA-approved drugs with similar transcriptional profiles.