Mx1-Cre-mediated Rac1 knockout confers multiple protective effects against anthracycline-induced acute normal tissue injury
Pelin Kücük, Sophie Gatzmanga, Jana Aengenvoort, Christian Henninger, Caroline Heinrich, Arthiga Vijayendran, Gerhard Fritz
This study shows that Rac1 deletion reduces anthracycline-induced organ damage in mice, with effects varying by organ and drug type.
bioRxiv · Jul 3, 2025 · PreprintPharmacology & Toxicology