Challenges and advances for huntingtin detection in cerebrospinal fluid: in support of relative quantification
Rachel Harding, Yuanyun Xie, Nicholas S. Caron, Hailey Findlay Black, Caroline Lyu, Nalini Potluri, Renu Chandrasekaran, Michael R. Hayden, Blair R. Leavitt, Douglas R. Langbehn, Amber L. Southwell
This study investigates challenges in mHTT quantification in CSF, showing that absolute quantitation is unreliable due to protein complexity and recommends relative quantitation instead.
Biomarker Research · Apr 21, 2025Peer-reviewedNeuroscience