Amber L. Southwell

This study investigates neuron-derived extracellular vesicles as non-invasive biomarkers for HTT protein and RNA in Huntington disease, showing subtype-specific differences in HTT levels.

This study investigates challenges in mHTT quantification in CSF, showing that absolute quantitation is unreliable due to protein complexity and recommends relative quantitation instead.

The paper introduces a tool to automate regional brain atrophy assessment in mouse models, showing high agreement with manual methods and reduced variability.

This study investigates how aging and oxidative stress interact in Huntington disease neurons from mice and humans, finding that aging accelerates mutant HTT accumulation and increases oxidative stress sensitivity.

This study shows that scheduled feeding and prevention of caspase-6 cleavage enhance autophagic clearance of mutant huntingtin in HD models and patients.