Nicholas S. Caron

This study identifies proteomic signatures in CSF and serum from HDClarity that can stage and stratify Huntington disease across clinical stages with high accuracy.

This study investigates challenges in mHTT quantification in CSF, showing that absolute quantitation is unreliable due to protein complexity and recommends relative quantitation instead.

This study identifies early neurodevelopmental defects in juvenile-onset HD driven by choroid plexus overgrowth and altered paracrine signaling using organoid and mouse models.

The paper shows reduced S-acylation of SQSTM1/p62 in Huntington disease impairs autophagy by blocking autophagic flux and causing empty autophagosomes.

This study investigates the role of HTT palmitoylation in Huntington disease by assessing its dysregulation in models and showing that modulating palmitoylation reduces mHTT toxicity.

This study investigates how aging and oxidative stress interact in Huntington disease neurons from mice and humans, finding that aging accelerates mutant HTT accumulation and increases oxidative stress sensitivity.

The paper identifies novel modifier genes for Huntington disease by combining population-scale gene expression data with patient genomic data.

This study shows that scheduled feeding and prevention of caspase-6 cleavage enhance autophagic clearance of mutant huntingtin in HD models and patients.