Douglas R. Langbehn

Challenges and advances for huntingtin detection in cerebrospinal fluid: in support of relative quantification

This study investigates challenges in mHTT quantification in CSF, showing that absolute quantitation is unreliable due to protein complexity and recommends relative quantitation instead.

Increased frequency of repeat expansion mutations across different populations

The paper estimates the frequency of repeat expansion mutations across populations using whole genome sequencing data and finds higher expected prevalence than current reports.

Impact of Binge Drinking During College on Resting State Functional Connectivity

This study examines how different levels of binge drinking during college affect resting state functional connectivity over time, finding decreased connectivity in specific brain networks associated with attention and self-focused processes.

Activity or Connectivity? Evaluating neurofeedback training in Huntington’s disease

This study evaluates neurofeedback training in Huntington’s disease, finding that while it can guide brain activity regulation, there was no robust evidence of clinical benefit or transfer of learning.