Effect of MisMatch Repair Deficiency on metastasis occurrence modelized in a syngeneic mouse model
Pierre Laplante, Reginaldo Rosa, Laëtitia Nebot-Bral, Jordane Goulas, Caroline Pouvelle, Sergey I. Nikolaev, Aymeric Silvin, Patricia L Kannouche
This study develops a syngeneic mouse model of MSI cancer and shows that immune responses regulate metastasis in MSI-H tumors, with specific immune cell infiltration observed in metastatic sites.
Neoplasia · Feb 21, 2025Peer-reviewedCancer Biology