Sergey I. Nikolaev

This study uses scRNA-seq to compare treatment-naive and post-treatment colorectal cancer samples, identifying markers and cell types associated with chemoresistance and response.

This study develops a syngeneic mouse model of MSI cancer and shows that immune responses regulate metastasis in MSI-H tumors, with specific immune cell infiltration observed in metastatic sites.

This study identifies TSPO-mediated mitochondrial-nuclear contacts as a mechanism enabling glioblastoma cells to evade TMZ chemotherapy, showing that modulating TSPO restores chemosensitivity.

The paper identifies an AH>GH substitution signature in mtDNA linked to aging and TSSS, showing higher frequency in species with longer generation lengths.

The paper investigates mtDNA mutational spectra across species and tissues, finding a correlation between AH>GH substitutions and longevity, suggesting it as a potential oxidative damage signature in mtDNA.