The Glycolytic Metabolite Methylglyoxal Covalently Inactivates the NLRP3 Inflammasome.
Caroline Stanton, Chavin Buasakdi, Jie Sun, Ian Levitan, Prerona Bora, Sergei Kutseikin, R. Luke Wiseman, Michael J. Bollong
This study shows methylglyoxal, a glycolytic metabolite, covalently inactivates the NLRP3 inflammasome by forming crosslinks, thereby reducing inflammation.
bioRxiv · Apr 19, 2024Cell Biology