Author

Chavin Buasakdi

Scripps Research InstituteORCID 0000-0002-5813-1084Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Caroline R. StantoniD· 2 shared Michael J. BollongiD· 2 shared Prerona BoraiD· 2 shared R. Luke WisemaniD· 2 shared Ian M. LevitaniD· 1 shared Jie SuniD· 1 shared Priyadarshini ChatterjeeiD· 1 shared Sergei KutseikiniD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

Caroline R. StantonORCID

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2 papers

Recent·Most cited

BiochemistryACS Chemical BiologyPeer-reviewedJul 29, 2025

Optimizing PDIA1 Inhibition as a Strategy to Inhibit NLRP3 Inflammasome Activation and Activity

Chavin Buasakdi, Caroline R. Stanton, Prerona Bora…·R. Luke Wiseman

This study identifies potent PDIA1 inhibitors that block NLRP3 inflammasome activity without significant cellular toxicity, offering a strategy to treat diseases involving hyperactive NLRP3.

DOI 10.1021/acschembio.5c00221

experimental assayhost-pathogen & immune response

𝕏 PostBluesky

Cell BiologyCell ReportsPeer-reviewedAug 27, 2024

The Glycolytic Metabolite Methylglyoxal Covalently Inactivates the NLRP3 Inflammasome.

Caroline R. Stanton, Chavin Buasakdi, Jie Sun…·Michael J. Bollong

This study shows methylglyoxal, a glycolytic metabolite, covalently inactivates the NLRP3 inflammasome by forming crosslinks, thereby reducing inflammation.

12 citations

humanproteomics

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