Prerona Bora

This study shows that IXA4 inhibits SLC33A1, causing ER hyperoxidation and activating IRE1/XBP1s signaling, which reduces viability of KEAP1-deficient lung cancer cells.

The paper identifies two compounds that activate the HRI pathway, improving mitochondrial function in MFN2-deficient cells.

This study identifies potent PDIA1 inhibitors that block NLRP3 inflammasome activity without significant cellular toxicity, offering a strategy to treat diseases involving hyperactive NLRP3.

This study shows that pharmacologic activation of ISR kinases HRI or GCN2 prevents mitochondrial fragmentation in disease models.

This study shows methylglyoxal, a glycolytic metabolite, covalently inactivates the NLRP3 inflammasome by forming crosslinks, thereby reducing inflammation.